Replacement of the Disulfide Bridge in a KLK3-Stimulating Peptide Using Orthogonally Protected Building Blocks

[Image: see text] Peptide “B-2”, which is one of the most potent kallikrein-related peptidase 3 (KLK3)-stimulating compounds, consists of 12 amino acids and is cyclized by a disulfide bridge between the N- and C-terminal cysteines. Orthogonally protected building blocks were used in the peptide synt...

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Main Authors: Meinander, Kristian, Pakkala, Miikka, Weisell, Janne, Stenman, Ulf-Håkan, Koistinen, Hannu, Närvänen, Ale, Wallén, Erik A. A.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027621/
https://ncbi.nlm.nih.gov/pubmed/24900791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400419g
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