Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate

[Image: see text] Starting from indole-based hepatitis C virus (HCV) NS5B polymerase inhibitor lead compound 1, structure modifications were performed at multiple indole substituents to improve potency and pharmacokinetic (PK) properties. Bicyclic quinazolinone was found to be the best substituent a...

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में बचाया:
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मुख्य लेखकों: Chen, Kevin X., Venkatraman, Srikanth, Anilkumar, Gopinadhan N., Zeng, Qingbei, Lesburg, Charles A., Vibulbhan, Bancha, Velazquez, Francisco, Chan, Tin-Yau, Bennet, Frank, Jiang, Yueheng, Pinto, Patrick, Huang, Yuhua, Selyutin, Oleg, Agrawal, Sony, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A., Rosenblum, Stuart B., Njoroge, F. George
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2013
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027611/
https://ncbi.nlm.nih.gov/pubmed/24900812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400192w
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