Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist

[Image: see text] LSP1-2111 is a group III metabotropic glutamate receptor agonist with preference toward the mGlu4 receptor subtype. This compound has been extensively used as a tool to explore the pharmacology of mGlu4 receptor activation in preclinical animal behavioral models. However, the blood...

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Autori principali: Cajina, Manuel, Nattini, Megan, Song, Dekun, Smagin, Gennady, Jørgensen, Erling B., Chandrasena, Gamini, Bundgaard, Christoffer, Toft, Dorthe Bach, Huang, Xinyan, Acher, Francine, Doller, Dario
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027608/
https://ncbi.nlm.nih.gov/pubmed/24900783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400338f
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