Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells

[Image: see text] Aberration in cell cycle has been shown to be a common occurrence in lung cancer, and cell cycle inhibitor represents an effective therapeutic strategy. In this study, we test the effects of a natural macrocyclic depsipeptide largazole on lung cancer cells and report that this comp...

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Bibliografiske detaljer
Main Authors: Wu, Li-Chuan, Wen, Zhe-Sheng, Qiu, Ya-Tao, Chen, Xiao-Qin, Chen, Hao-Bin, Wei, Ming-Ming, Liu, Zi, Jiang, Sheng, Zhou, Guang-Biao
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027503/
https://ncbi.nlm.nih.gov/pubmed/24900585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400093y
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