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De Novo Prediction of P-Glycoprotein-Mediated Efflux Liability for Druglike Compounds
[Image: see text] P-glycoprotein (Pgp) is capable of recognizing and transporting a wide range of chemically diverse compounds in vivo. Overcoming Pgp-mediated efflux can represent a significant challenge when penetration into the central nervous system is required or within the context of developin...
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| Main Authors: | , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2012
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027482/ https://ncbi.nlm.nih.gov/pubmed/24900570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300314h |
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