Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation

[Image: see text] In order to identify novel Alzheimer’s modifying pharmacological tools, we developed bis-tacrines bearing a peptide moiety for specific interference with surface sites of human acetylcholinesterase (hAChE) binding amyloid-beta (Aβ). Accordingly, compounds 2a–c proved to be inhibito...

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Detalhes bibliográficos
Main Authors: Butini, Stefania, Brindisi, Margherita, Brogi, Simone, Maramai, Samuele, Guarino, Egeria, Panico, Alessandro, Saxena, Ashima, Chauhan, Ved, Colombo, Raffaella, Verga, Laura, De Lorenzi, Ersilia, Bartolini, Manuela, Andrisano, Vincenza, Novellino, Ettore, Campiani, Giuseppe, Gemma, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027481/
https://ncbi.nlm.nih.gov/pubmed/24900626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002908
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