Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species

[Image: see text] Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closin...

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Główni autorzy: Sanguinetti, Maurizio, Sanfilippo, Stefania, Castagnolo, Daniele, Sanglard, Dominique, Posteraro, Brunella, Donzellini, Giovanni, Botta, Maurizio
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2013
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027461/
https://ncbi.nlm.nih.gov/pubmed/24900759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400187w
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