Loss of Mitochondrial Functions Associated with Azole Resistance in Candida glabrata Results in Enhanced Virulence in Mice

Mitochondrial dysfunction is one of the possible mechanisms by which azole resistance can occur in Candida glabrata. Cells with mitochondrial DNA deficiency (so-called “petite mutants”) upregulate ATP binding cassette (ABC) transporter genes and thus display increased resistance to azoles. Isolation...

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Detalhes bibliográficos
Main Authors: Ferrari, Sélène, Sanguinetti, Maurizio, De Bernardis, Flavia, Torelli, Riccardo, Posteraro, Brunella, Vandeputte, Patrick, Sanglard, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088236/
https://ncbi.nlm.nih.gov/pubmed/21321146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01271-10
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