Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC(2) Agonism and Glucose-Dependent Insulin Secretion

[Image: see text] Agonists of vasoactive intestinal peptide receptor 2 (VPAC(2)) stimulate glucose-dependent insulin secretion, making them attractive candidates for the treatment of hyperglycaemia and type-II diabetes. Vasoactive intestinal peptide (VIP) is an endogenous peptide hormone that potent...

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Bibliographic Details
Main Authors: Giordanetto, Fabrizio, Revell, Jefferson D., Knerr, Laurent, Hostettler, Marie, Paunovic, Amalia, Priest, Claire, Janefeldt, Annika, Gill, Adrian
Format: Artigo
Language:Inglês
Published: American Chemical Society 2013
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027235/
https://ncbi.nlm.nih.gov/pubmed/24900623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400257h
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