Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4-Aminoquinoline-Based Compounds

[Image: see text] A new class of 4-aminoquinolines was synthesized and evaluated in vitro for antiplasmodial activity against both the chloroquine-sensitive (3D7) and -resistant (K1 and W2) strains. The most active compounds 3c–3e had acceptable cytotoxicity but showed strong inhibition toward a pan...

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Main Authors: Tukulula, Matshawandile, Njoroge, Mathew, Abay, Efrem T., Mugumbate, Grace C., Wiesner, Lubbe, Taylor, Dale, Gibhard, Liezl, Norman, Jennifer, Swart, Kenneth J., Gut, Jiri, Rosenthal, Philip J., Barteau, Samuel, Streckfuss, Judith, Kameni-Tcheudji, Jacques, Chibale, Kelly
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027225/
https://ncbi.nlm.nih.gov/pubmed/24900630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400311r
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