A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homology directed repair (HDR). Identifying novel small molecules that affect HDR is of great importance both for research use and therapy. Molecules that elevate HDR may improv...

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Detalhes bibliográficos
Main Authors: Shahar, Or David, Kalousi, Alkmini, Eini, Lital, Fisher, Benoit, Weiss, Amelie, Darr, Jonatan, Mazina, Olga, Bramson, Shay, Kupiec, Martin, Eden, Amir, Meshorer, Eran, Mazin, Alexander V., Brino, Laurent, Goldberg, Michal, Soutoglou, Evi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027216/
https://ncbi.nlm.nih.gov/pubmed/24682826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku217
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