The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast

DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear. Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (...

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Autori principali: Blaikley, Elizabeth J., Tinline-Purvis, Helen, Kasparek, Torben R., Marguerat, Samuel, Sarkar, Sovan, Hulme, Lydia, Hussey, Sharon, Wee, Boon-Yu, Deegan, Rachel S., Walker, Carol A., Pai, Chen-Chun, Bähler, Jürg, Nakagawa, Takuro, Humphrey, Timothy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027169/
https://ncbi.nlm.nih.gov/pubmed/24623809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku190
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