The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast

The formation of RNA–DNA hybrids, referred to as R-loops, can promote genome instability and cancer development. Yet the mechanisms by which R-loops compromise genome instability are poorly understood. Here, we establish roles for the evolutionarily conserved Nrl1 protein in pre-mRNA splicing regula...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Aronica, Lucia, Kasparek, Torben, Ruchman, David, Marquez, Yamile, Cipak, Lubos, Cipakova, Ingrid, Anrather, Dorothea, Mikolaskova, Barbora, Radtke, Maximilian, Sarkar, Sovan, Pai, Chen-Chun, Blaikley, Elizabeth, Walker, Carol, Shen, Kuo-Fang, Schroeder, Renee, Barta, Andrea, Forsburg, Susan L., Humphrey, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770224/
https://ncbi.nlm.nih.gov/pubmed/26682798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1473
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