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Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

[Image: see text] Acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. It is an important target for both therapeutic drugs that treat Alzheimer’s disease and chemical warfare agents that cripple...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cheung, Jonah, Gary, Ebony N., Shiomi, Kazuro, Rosenberry, Terrone L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027152/
https://ncbi.nlm.nih.gov/pubmed/24900610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400304w
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