Recombinant bovine respiratory syncytial virus with deletion of the SH gene induces increased apoptosis and pro-inflammatory cytokines in vitro, and is attenuated and induces protective immunity in calves

Bovine respiratory syncytial virus (BRSV) causes inflammation and obstruction of the small airways, leading to severe respiratory disease in young calves. The virus is closely related to human (H)RSV, a major cause of bronchiolitis and pneumonia in young children. The ability to manipulate the genom...

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Detalhes bibliográficos
Main Authors: Taylor, Geraldine, Wyld, Sara, Valarcher, Jean-Francois, Guzman, Efrain, Thom, Michelle, Widdison, Stephanie, Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2014
Assuntos:
Animal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027036/
https://ncbi.nlm.nih.gov/pubmed/24700100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.064931-0
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