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Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes
Background: The activity of thiopurine methyltransferase (TPMT) is subject to genetic variation. Loss-of-function alleles are associated with various degrees of myelosuppression after treatment with thiopurine drugs, thus genotype-based dosing recommendations currently exist. The aim of this study w...
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| Prif Awduron: | , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Frontiers Media S.A.
2014
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026736/ https://ncbi.nlm.nih.gov/pubmed/24860591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00096 |
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