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High frequency of rare variants with a moderate-to-high predicted biological effect in protocadherin genes of extremely obese

Relatively rare variants with a moderate-to-high biological effect may contribute to the genetic predisposition of common disorders. To investigate this for obesity, we performed exome sequencing for 30 young (mean age: 29.7 years) extremely obese Caucasian subjects (mean body mass index: 51.1 kg/m(...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Mariman, Edwin C. M., Bouwman, F. G., Aller, Erik E. J. G., van Baak, Marleen A., Wang, Ping
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Berlin Heidelberg 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026441/
https://ncbi.nlm.nih.gov/pubmed/24682882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12263-014-0399-1
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