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Tumor cells and memory T cells converge at glycolysis: Therapeutic implications

In the immune system, activation of naïve T (T(n)) cells into effector T cells (T(eff)) involves a metabolic switch to glycolysis to promote rapid proliferation and differentiation. In the October issue of The Journal of Clinical Investigation, Sukumar et al. have demonstrated that in CD8(+) memory...

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Autori principali: Karthikeyan, Swathi, Geschwind, Jean-Francois, Ganapathy-Kanniappan, Shanmugasundaram
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026068/
https://ncbi.nlm.nih.gov/pubmed/24556820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28160
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