Protector turns predator: Autophagic death via selective degradation of KRAS

Therapy-induced autophagy is recognized as a critical determinant of treatment outcome in cancer patients, primarily as a factor underlying drug resistance. However, recent investigations point toward a context-dependent, death-inducing role for autophagy, the mechanism of which remains largely unkn...

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Bibliographic Details
Main Authors: Kohli, Latika, Kaza, Niroop, Carroll, Steven L., Roth, Kevin A.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Autophagic Punctum
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026028/
https://ncbi.nlm.nih.gov/pubmed/24121562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.25837
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