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Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder

The large-conductance, voltage-dependent and Ca(2+)-dependent K(+) (BK) channel links membrane depolarization and local increases in cytosolic free Ca(2+) to hyperpolarizing K(+) outward currents, thereby controlling smooth muscle contractility. Constitutive deletion of the BK channel in mice (BK(−/...

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Detalhes bibliográficos
Main Authors: Sprossmann, Franz, Pankert, Patrick, Sausbier, Ulrike, Wirth, Angela, Zhou, Xiao-Bo, Madlung, Johannes, Zhao, Hong, Bucurenciu, Iancu, Jakob, Andreas, Lamkemeyer, Tobias, Neuhuber, Winfried, Offermanns, Stefan, Shipston, Michael J., Korth, Michael, Nordheim, Alfred, Ruth, Peter, Sausbier, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025950/
https://ncbi.nlm.nih.gov/pubmed/19220851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.06900.x
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