Osteopenia Due to Enhanced Cathepsin K Release by BK Channel Ablation in Osteoclasts

BACKGROUND: The process of bone resorption by osteoclasts is regulated by Cathepsin K, the lysosomal collagenase responsible for the degradation of the organic bone matrix during bone remodeling. Recently, Cathepsin K was regarded as a potential target for therapeutic intervention of osteoporosis. H...

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Detalhes bibliográficos
Main Authors: Sausbier, Ulrike, Dullin, Christian, Missbach-Guentner, Jeannine, Kabagema, Clement, Flockerzie, Katarina, Kuscher, Gerd Marten, Stuehmer, Walter, Neuhuber, Winfried, Ruth, Peter, Alves, Frauke, Sausbier, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114853/
https://ncbi.nlm.nih.gov/pubmed/21695131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021168
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