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Structure–Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway

[Image: see text] Oxysterols (OHCs) are byproducts of cholesterol oxidation that are known to activate the Hedeghog (Hh) signaling pathway. While OHCs that incorporate hydroxyl groups throughout the scaffold are known, those that act as agonists of Hh signaling primarily contain a single hydroxyl on...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Corman, Audrey, DeBerardinis, Albert M., Hadden, M. Kyle
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2012
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025875/
https://ncbi.nlm.nih.gov/pubmed/24900386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300192k
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