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Ring Structure and Aromatic Substituent Effects on the pK(a) of the Benzoxaborole Pharmacophore

[Image: see text] In this work, we present an investigation into the physical properties of a unique class of aromatic boronic acids, the benzoxaboroles. Using spectrophotometric methods, the ionization constants of a family of substituted benzoxaboroles are determined. Heterocyclic ring modificatio...

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Detalhes bibliográficos
Main Authors: Tomsho, John W., Pal, Arnab, Hall, Dennis G., Benkovic, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025869/
https://ncbi.nlm.nih.gov/pubmed/24900370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200215j
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