Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

[Image: see text] Kynurenine aminotransferase (KAT) II has been identified as a potential new target for the treatment of cognitive impairment associated with schizophrenia and other psychiatric disorders. Following a high-throughput screen, cyclic hydroxamic acid PF-04859989 was identified as a pot...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Dounay, Amy B., Anderson, Marie, Bechle, Bruce M., Campbell, Brian M., Claffey, Michelle M., Evdokimov, Artem, Evrard, Edelweiss, Fonseca, Kari R., Gan, Xinmin, Ghosh, Somraj, Hayward, Matthew M., Horner, Weldon, Kim, Ji-Young, McAllister, Laura A., Pandit, Jayvardhan, Paradis, Vanessa, Parikh, Vinod D., Reese, Matthew R., Rong, SuoBao, Salafia, Michelle A., Schuyten, Katherine, Strick, Christine A., Tuttle, Jamison B., Valentine, James, Wang, Hong, Zawadzke, Laura E., Verhoest, Patrick R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2012
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025856/
https://ncbi.nlm.nih.gov/pubmed/24900455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200204m
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk