Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

[Image: see text] Kynurenine aminotransferase (KAT) II has been identified as a potential new target for the treatment of cognitive impairment associated with schizophrenia and other psychiatric disorders. Following a high-throughput screen, cyclic hydroxamic acid PF-04859989 was identified as a pot...

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Xehetasun bibliografikoak
Egile Nagusiak: Dounay, Amy B., Anderson, Marie, Bechle, Bruce M., Campbell, Brian M., Claffey, Michelle M., Evdokimov, Artem, Evrard, Edelweiss, Fonseca, Kari R., Gan, Xinmin, Ghosh, Somraj, Hayward, Matthew M., Horner, Weldon, Kim, Ji-Young, McAllister, Laura A., Pandit, Jayvardhan, Paradis, Vanessa, Parikh, Vinod D., Reese, Matthew R., Rong, SuoBao, Salafia, Michelle A., Schuyten, Katherine, Strick, Christine A., Tuttle, Jamison B., Valentine, James, Wang, Hong, Zawadzke, Laura E., Verhoest, Patrick R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2012
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025856/
https://ncbi.nlm.nih.gov/pubmed/24900455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200204m
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