Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

[Image: see text] Kynurenine aminotransferase (KAT) II has been identified as a potential new target for the treatment of cognitive impairment associated with schizophrenia and other psychiatric disorders. Following a high-throughput screen, cyclic hydroxamic acid PF-04859989 was identified as a pot...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Dounay, Amy B., Anderson, Marie, Bechle, Bruce M., Campbell, Brian M., Claffey, Michelle M., Evdokimov, Artem, Evrard, Edelweiss, Fonseca, Kari R., Gan, Xinmin, Ghosh, Somraj, Hayward, Matthew M., Horner, Weldon, Kim, Ji-Young, McAllister, Laura A., Pandit, Jayvardhan, Paradis, Vanessa, Parikh, Vinod D., Reese, Matthew R., Rong, SuoBao, Salafia, Michelle A., Schuyten, Katherine, Strick, Christine A., Tuttle, Jamison B., Valentine, James, Wang, Hong, Zawadzke, Laura E., Verhoest, Patrick R.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2012
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025856/
https://ncbi.nlm.nih.gov/pubmed/24900455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200204m
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