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Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA
[Image: see text] Thirty-two diverse compounds were evaluated for their ability to inhibit both Pgp-mediated efflux in mouse T-lymphoma L5178 MDR1 and NorA-mediated efflux in S. aureus SA-1199B. Only four compounds were strong inhibitors of both efflux pumps. Three compounds were found to inhibit Pg...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2012
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4025771/ https://ncbi.nlm.nih.gov/pubmed/24900460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200293c |
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