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BACE1 Inhibitor Peptides: Can an Infinitely Small k(cat) Value Turn the Substrate of an Enzyme into Its Inhibitor?
[Image: see text] Recently, we reported substrate-based pentapeptidic β-secretase (BACE1) inhibitors with a hydroxymethylcarbonyl isostere as a substrate transition-state mimic. These inhibitors showed potent BACE1 inhibitory activity in enzyme and cell assays, with KMI-429 showing in vivo inhibitio...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4025764/ https://ncbi.nlm.nih.gov/pubmed/24900449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2002373 |
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