Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents

[Image: see text] NDH-2 is an essential respiratory enzyme in Mycobacterium tuberculosis (Mtb), which plays an important role in the physiology of Mtb. Herein, we present a target-based effort to identify a new structural class of inhibitors for NDH-2. High-throughput screening of the AstraZeneca co...

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Hlavní autoři: Shirude, Pravin S., Paul, Beena, Roy Choudhury, Nilanjana, Kedari, Chaitanya, Bandodkar, Balachandra, Ugarkar, Bheemarao G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025736/
https://ncbi.nlm.nih.gov/pubmed/24900541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300134b
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