Mechanistic and Bioinformatic Investigation of a Conserved Active Site Helix in α-Isopropylmalate Synthase from Mycobacterium tuberculosis, a Member of the DRE-TIM Metallolyase Superfamily

[Image: see text] The characterization of functionally diverse enzyme superfamilies provides the opportunity to identify evolutionarily conserved catalytic strategies, as well as amino acid substitutions responsible for the evolution of new functions or specificities. Isopropylmalate synthase (IPMS)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Casey, Ashley K., Hicks, Michael A., Johnson, Jordyn L., Babbitt, Patricia C., Frantom, Patrick A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025573/
https://ncbi.nlm.nih.gov/pubmed/24720347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500246z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados