Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain

In response to neuronal injury or disease, microglia adopt distinct reactive phenotypes via the expression of different sets of genes. Spinal microglia expressing the purinergic P2X4 receptor (P2X4R) after peripheral nerve injury (PNI) are implicated in neuropathic pain. Here we show that interferon...

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Main Authors: Masuda, Takahiro, Iwamoto, Shosuke, Yoshinaga, Ryohei, Tozaki-Saitoh, Hidetoshi, Nishiyama, Akira, Mak, Tak W., Tamura, Tomohiko, Tsuda, Makoto, Inoue, Kazuhide
格式: Artigo
語言:Inglês
出版: Nature Pub. Group 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024744/
https://ncbi.nlm.nih.gov/pubmed/24818655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4771
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