Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing

PURPOSE: To describe sources of interindividual variability in bevacizumab disposition in pediatric patients and explore associations among bevacizumab pharmacokinetics and clinical wound healing outcomes. EXPERIMENTAL DESIGN: Prior to tumor resection, three doses of bevacizumab (15 mg/kg) were admi...

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Detalhes bibliográficos
Main Authors: Turner, David C., Navid, Fariba, Daw, Najat C., Mao, Shenghua, Wu, Jianrong, Santana, Victor M., Neel, Michael, Rao, Bhaskar, Willert, Jennifer Reikes, Loeb, David M., Harstead, K. Elaine, Throm, Stacy L., Freeman, Burgess B., Stewart, Clinton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024352/
https://ncbi.nlm.nih.gov/pubmed/24637635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2364
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