BRCA1 DEFICIENCY EXACERBATES ESTROGEN INDUCED DNA DAMAGE AND GENOMIC INSTABILITY

Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell cycle arrest and transcriptional control. A major question has been why BRCA1 loss or mutation leads to tumors m...

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Xehetasun bibliografikoak
Egile Nagusiak: Savage, Kienan I., Matchett, Kyle B., Barros, Eliana M., Cooper, Kevin M., Irwin, Gareth W., Gorski, Julia J., Orr, Katy S., Vohhodina, Jekaterina, Kavanagh, Joy N., Madden, Angelina F., Powell, Alexander, Manti, Lorenzo, McDade, Simon S., Park, Ben Ho, Prise, Kevin M., McIntosh, Stuart A., Salto-Tellez, Manuel, Richard, Derek J., Elliott, Christopher T., Harkin, D. Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024319/
https://ncbi.nlm.nih.gov/pubmed/24638981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2611
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