BRCA1 DEFICIENCY EXACERBATES ESTROGEN INDUCED DNA DAMAGE AND GENOMIC INSTABILITY

Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell cycle arrest and transcriptional control. A major question has been why BRCA1 loss or mutation leads to tumors m...

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Hoofdauteurs: Savage, Kienan I., Matchett, Kyle B., Barros, Eliana M., Cooper, Kevin M., Irwin, Gareth W., Gorski, Julia J., Orr, Katy S., Vohhodina, Jekaterina, Kavanagh, Joy N., Madden, Angelina F., Powell, Alexander, Manti, Lorenzo, McDade, Simon S., Park, Ben Ho, Prise, Kevin M., McIntosh, Stuart A., Salto-Tellez, Manuel, Richard, Derek J., Elliott, Christopher T., Harkin, D. Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024319/
https://ncbi.nlm.nih.gov/pubmed/24638981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2611
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