HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse

Acute promyelocytic leukemia (APL) is epitomized by the chromosomal translocation t(15;17) and the resulting oncogenic fusion protein PML-RARα. Although acting primarily as a transcriptional repressor, PML-RARα can also exert functions of transcriptional co-activation. Here, we find that PML-RARα st...

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Autors principals: Coltella, Nadia, Percio, Stefano, Valsecchi, Roberta, Cuttano, Roberto, Guarnerio, Jlenia, Ponzoni, Maurilio, Pandolfi, Pier Paolo, Melillo, Giovanni, Pattini, Linda, Bernardi, Rosa
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023886/
https://ncbi.nlm.nih.gov/pubmed/24711541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303065
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