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Impact of Renal Function on the Pharmacokinetics and Safety of Ceftolozane-Tazobactam

Ceftolozane-tazobactam is a novel antipseudomonal cephalosporin with a β-lactamase inhibitor. We investigated the pharmacokinetics (PK) and safety of ceftolozane-tazobactam in subjects with various degrees of renal function. In two phase I, open-label studies, a single dose of ceftolozane-tazobactam...

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Autori principali: Wooley, Myra, Miller, Benjamin, Krishna, Gopal, Hershberger, Ellie, Chandorkar, Gurudatt
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023800/
https://ncbi.nlm.nih.gov/pubmed/24492369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02151-13
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