Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile

Clostridium difficile is the causative agent of C. difficile-associated diarrhea (CDAD), with increased risk in elderly populations. Kibdelomycin, a novel natural-product inhibitor of type II topoisomerase enzymes, was evaluated for activity against C. difficile and gastrointestinal anaerobic organi...

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Autors principals: Miesel, Lynn, Hecht, David W., Osmolski, James R., Gerding, Dale, Flattery, Amy, Li, Fangbiao, Lan, Jing, Lipari, Philip, Polishook, Jon D., Liang, Lianzhu, Liu, Jenny, Olsen, David B., Singh, Sheo B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023737/
https://ncbi.nlm.nih.gov/pubmed/24514098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00021-14
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