Sphingolipid Biosynthetic Pathway Genes FEN1 and SUR4 Modulate Amphotericin B Resistance

Deletants of the sphingolipid biosynthetic pathway genes FEN1 and SUR4 of Saccharomyces cerevisiae, as well as deletants of their orthologs in Candida albicans, were found to be 2- to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The inhibition of sphingolipid biosynthesis in pa...

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Detaylı Bibliyografya
Asıl Yazarlar: Sharma, Sushma, Alfatah, Md., Bari, Vinay K., Rawal, Yashpal, Paul, Sanjoy, Ganesan, K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Mechanisms of Resistance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023708/
https://ncbi.nlm.nih.gov/pubmed/24395234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02130-13
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