Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors

BACKGROUND: HSP90 inhibition leads to proteosomal degradation of activated KIT and has in vitro activity against gastrointestinal stromal tumors (GIST). BIIB021 is an oral non-ansamycin HSP90 inhibitor. We carried out a phase II study of BIIB021 in patients with GIST refractory to imatinib and sunit...

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Détails bibliographiques
Auteurs principaux: Dickson, M. A., Okuno, S. H., Keohan, M. L., Maki, R. G., D'Adamo, D. R., Akhurst, T. J., Antonescu, C. R., Schwartz, G. K.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023320/
https://ncbi.nlm.nih.gov/pubmed/22898035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mds275
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