Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance

AIM: To investigate the effects of BIIB021, an inhibitor of heat shock protein 90 (Hsp90) alone or in combination with triptolide (TPL) on T-cell acute lymphoblastic leukemia (T-ALL) and the mechanisms of action. METHODS: Human T-ALL cells line Molt-4 was examined. The cell viability was measured us...

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Main Authors: Li, Min, Zhang, Xiang, Zhou, Wen-jing, Chen, Yue-hua, Liu, Hui, Liu, Lin, Yang, Chun-mei, Qian, Wen-bin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002565/
https://ncbi.nlm.nih.gov/pubmed/24241349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.124
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