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Dynamics of Hepatitis C Virus (HCV) RNA-dependent RNA Polymerase NS5B in Complex with RNA

The hepatitis C virus (HCV) non-structural protein 5B (NS5B) is an RNA-dependent RNA polymerase that is essentially required for viral replication. Although previous studies revealed important properties of static NS5B-RNA complexes, the nature and relevance of dynamic interactions have yet to be el...

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Autors principals: Karam, Pierre, Powdrill, Megan H., Liu, Hsiao-Wei, Vasquez, Colins, Mah, Wayne, Bernatchez, Jean, Götte, Matthias, Cosa, Gonzalo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022906/
https://ncbi.nlm.nih.gov/pubmed/24692556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529743
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