Muscarinic Control of MIN6 Pancreatic β Cells Is Enhanced by Impaired Amino Acid Signaling

We have shown recently that the class C G protein-coupled receptor T1R1/T1R3 taste receptor complex is an early amino acid sensor in MIN6 pancreatic β cells. Amino acids are unable to activate ERK1/2 in β cells in which T1R3 has been depleted. The muscarinic receptor agonist carbachol activated ERK1...

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Bibliografiske detaljer
Main Authors: Guerra, Marcy L., Wauson, Eric M., McGlynn, Kathleen, Cobb, Melanie H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022903/
https://ncbi.nlm.nih.gov/pubmed/24695728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565069
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