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ELIC-α7 Nicotinic Acetylcholine Receptor (α7nAChR) Chimeras Reveal a Prominent Role of the Extracellular-Transmembrane Domain Interface in Allosteric Modulation

The native α7 nicotinic acetylcholine receptor (α7nAChR) is a homopentameric ligand-gated ion channel mediating fast synaptic transmission and is of pharmaceutical interest for treatment of numerous disorders. The transmembrane domain (TMD) of α7nAChR has been identified as a target for positive all...

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Autors principals: Tillman, Tommy S., Seyoum, Edom, Mowrey, David D., Xu, Yan, Tang, Pei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022858/
https://ncbi.nlm.nih.gov/pubmed/24695730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524611
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