Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying neuromodulatory mechanisms are unknown. Previous studies revealed that Bhlhb5(−/−) mice, which lack a specifi...

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Main Authors: Kardon, Adam P., Polgár, Erika, Hachisuka, Junichi, Snyder, Lindsey M., Cameron, Darren, Savage, Sinead, Cai, Xiaoyun, Karnup, Sergei, Fan, Christopher R., Hemenway, Gregory M., Bernard, Carcha S., Schwartz, Erica S., Nagase, Hiroshi, Schwarzer, Christoph, Watanabe, Masahiko, Furuta, Takahiro, Kaneko, Takeshi, Koerber, H. Richard, Todd, Andrew J., Ross, Sarah E.
格式: Artigo
語言:Inglês
出版: Cell Press 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022838/
https://ncbi.nlm.nih.gov/pubmed/24726382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.02.046
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