Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying neuromodulatory mechanisms are unknown. Previous studies revealed that Bhlhb5(−/−) mice, which lack a specifi...

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Autori principali: Kardon, Adam P., Polgár, Erika, Hachisuka, Junichi, Snyder, Lindsey M., Cameron, Darren, Savage, Sinead, Cai, Xiaoyun, Karnup, Sergei, Fan, Christopher R., Hemenway, Gregory M., Bernard, Carcha S., Schwartz, Erica S., Nagase, Hiroshi, Schwarzer, Christoph, Watanabe, Masahiko, Furuta, Takahiro, Kaneko, Takeshi, Koerber, H. Richard, Todd, Andrew J., Ross, Sarah E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022838/
https://ncbi.nlm.nih.gov/pubmed/24726382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.02.046
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