Phosphorylation of the Proapoptotic BH3-Only Protein Bid Primes Mitochondria for Apoptosis during Mitotic Arrest

Mitosis is a moment of exquisite vulnerability for a metazoan cell. Failure to complete mitosis accurately can lead to aneuploidy and cancer initiation. Therefore, if the exit from mitosis is delayed, normal cells are usually removed by apoptosis. However, how failure to complete mitosis activates a...

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Bibliographic Details
Main Authors: Wang, Pengbo, Lindsay, Jennefer, Owens, Thomas W., Mularczyk, Ewa J., Warwood, Stacey, Foster, Fiona, Streuli, Charles H., Brennan, Keith, Gilmore, Andrew P.
Format: Artigo
Language:Inglês
Published: Cell Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022835/
https://ncbi.nlm.nih.gov/pubmed/24767991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.050
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