Bortezomib Treatment Produces Nocifensive Behavior and Changes in the Expression of TRPV1, CGRP, and Substance P in the Rat DRG, Spinal Cord, and Sciatic Nerve

To investigate neurochemical changes associated with bortezomib-induced painful peripheral neuropathy (PN), we examined the effects of a single-dose intravenous administration of bortezomib and a well-established “chronic” schedule in a rat model of bortezomib-induced PN. The TRPV1 channel and senso...

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Главные авторы: Quartu, M., Carozzi, V. A., Dorsey, S. G., Serra, M. P., Poddighe, L., Picci, C., Boi, M., Melis, T., Del Fiacco, M., Meregalli, C., Chiorazzi, A., Renn, C. L., Cavaletti, G., Marmiroli, P.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2014
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022313/
https://ncbi.nlm.nih.gov/pubmed/24877063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/180428
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