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Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer’s disease

Synapses are essential for transmitting, processing, and storing information, all of which decline in aging and Alzheimer’s disease (AD). Because synapse loss only partially accounts for the cognitive declines seen in aging and AD, we hypothesized that existing synapses might undergo molecular chang...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Berchtold, Nicole C., Coleman, Paul D., Cribbs, David H., Rogers, Joseph, Gillen, Daniel L., Cotman, Carl W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022280/
https://ncbi.nlm.nih.gov/pubmed/23273601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.11.024
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