Arsenic trioxide induces differentiation of CD133(+) hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model

BACKGROUND: Cancer stem cells (CSCs) play a key role in the posthepatectomy recurrence of hepatocellular carcinoma (HCC). CD133(+) HCC cells exhibit liver CSC–like properties, and CSC differentiation–inducing therapy may lead these cells to lose their self-renewal ability and may induce terminal dif...

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Detalhes bibliográficos
Main Authors: Zhang, Ke-Zhi, Zhang, Qiang-Bo, Zhang, Quan-Bao, Sun, Hui-Chuan, Ao, Jian-Yang, Chai, Zong-Tao, Zhu, Xiao-Dong, Lu, Lu, Zhang, Yuan-Yuan, Bu, Yang, Kong, Ling-Qun, Tang, Zhao-You
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022144/
https://ncbi.nlm.nih.gov/pubmed/24678763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-28
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