Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies

BACKGROUND: Porphyrin TMPyP4 (P4) and its C(14)H(28)-alkyl derivative (C14) are G-quadruplex binders and singlet oxygen ((1)O(2)) generators. In contrast, TMPyP2 (P2) produces (1)O(2) but it is not a G-quadruplex binder. As their photosensitizing activity is currently undefined, we report in this st...

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Bibliographic Details
Main Authors: Rapozzi, Valentina, Zorzet, Sonia, Zacchigna, Marina, Della Pietra, Emilia, Cogoi, Susanna, Xodo, Luigi E
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021972/
https://ncbi.nlm.nih.gov/pubmed/24684778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-75
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